More ideas:
- Sound off on a topic you're passionate about
- Create an interactive adventure
- Write a song with someone on the other side of the globe
- Show people what it's like to see -- literally -- from your eyes
- Record a word every day for a year, then compile in one video
- Upload a video response to Ben Stiller
- Construct a video time capsule not to be watched for five years
- Go on a roadtrip and share real-time updates along the way
- Give advice to those in need
- Contribute to an Internet meme
- Propose to your beloved
- Teach someone your language
- Honor someone who's died
- Review a film
- Order some caterpillars, and film your kids watching them turn into butterflies
- Create an interactive game
- Show 51 things around your house
- Reveal what the contents of your fridge say about you
- Zoom in on nature and marvel at its textures
- Teach others how to use YouTube
- Do your best Christopher Walken impersonation
- Ask an astronaut a question
- Comment on the weather
- Share a medical experience so others can know what to expect
- Tell a fairy tale in dominoes
- Use YouTube as your pulpit
- Perfect your elevator pitch
- Recreate Edgar Allen Poe for the YouTube generation